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Evidence is increasing that all addiction without exception is related to problems with the brain's reward center, particularly the mesolimbic system. This part of the problem regulates reward responses in acquiring food and sex, plus in nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both after they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008).
Using two separate drugs to shed weight can be very effective you'll find combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the people that go through it one should err assisting caution and let the FDA do its job and demand some research be done so your public understands the side effects and hazards of the medications before we take them. Keep in mind that drug companies have been in business to make money and that they would say everything to keep people on his or her medications.
Researchers found that participants investing in this drug for any year, dropped a few pounds within four weeks and have kept the weight off through the 56 weeks in the study. Contrave is often a combination of the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs which can be made up of several active ingredient, which may make them far better and safer.
Combo-pilling could be the newest fad or even better the newest to come under scrutiny and thus it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills has become popular may be the fact that since right now there are no long term prescription weight loss supplements that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be approved by the FDA.
Seizures are a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug could also raise blood pressure levels and pulse rate, and really should not be used in people who have a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.
The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must 't be used in patients with uncontrolled high blood pressure level, in addition to by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients using a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients to the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation.
The most common negative effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.